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26/08/2020 9:36 pm
Endocrine Society JCEM
This version published online on July 21, 2010
Journal of Clinical Endocrinology & Metabolism , doi:10.1210/jc.2010-0606
Submitted on March 15, 2010
Accepted on June 14, 2010
A 16-Week Randomized Clinical Trial of 2000 International Units Daily Vitamin D3 Supplementation in Black Youth: 25-Hydroxyvitamin D, Adiposity, and Arterial Stiffness
Yanbin Dong*, Inger S. Stallmann-Jorgensen, Norman K. Pollock, Ryan A. Harris, Daniel Keeton, Ying Huang, Ke Li, Reda Bassali, De-huang Guo, Jeffrey Thomas, Gary L. Pierce, Jennifer White, Michael F. Holick, and Haidong Zhu
Georgia Prevention Institute, Department of Pediatrics (Y.D., I.S.S.-J., N.K.P., R.A.H., D.K., Y.H., K.L., D.G., J.T., G.L.P., H.Z.); General Pediatrics, Department of Pediatrics (R.B.), and Endocrinology, Department of Medicine (J.W.), Medical College of Georgia, Augusta, Georgia 30912; and Endocrinology, Department of Medicine (M.F.H.), Boston University Medical Center, School of Medicine, Boston, Massachusetts 02118
* To whom correspondence should be addressed. E-mail: [email protected].
Context: Vitamin D insufficiency/deficiency is commonly observed in black youth.
Objective: The aim was to determine 25-hydroxyvitamin D [25(OH)D] in response to 2000 IU vitamin D supplementation over time; to evaluate the relation between 25(OH)D concentrations and total body fat mass by dual-energy x-ray absorptiometry; and to determine whether vitamin D supplementation improves arterial stiffness measured by pulse wave velocity (PWV).
Design: We conducted a randomized, blinded, controlled clinical trial.
Setting and Participants: Forty-nine normotensive black boys and girls, aged 16.3 ± 1.4 yr, were randomly assigned to either the control group (400 IU/d; n = 24) or the experimental group (2000 IU/d; n = 25).
Results: Plasma 25(OH)D values at baseline and at 4, 8, and 16 wk were 34.0 ± 10.6, 44.9 ± 9.4, 51.2 ± 11.1, and 59.8 ± 18.2 nmol/liter, respectively, for the control group; and 33.1 ± 8.7, 55.0 ± 11.8, 70.9 ± 22.0, and 85.7 ± 30.1 nmol/liter, respectively, for the experimental group. The experimental group vs. the control group reached significantly higher 25(OH)D concentrations at 8 and 16 wk, respectively. Partial correlation analyses indicated that total body fat mass at baseline was significantly and inversely associated with 25(OH)D concentrations in response to the 2000-IU supplement across time. Furthermore, carotid-femoral PWV increased from baseline (5.38 ± 0.53 m/sec) to posttest (5.71 ± 0.75 m/sec) in the control group (P = 0.016), whereas in the experimental group carotid-femoral PWV decreased from baseline (5.41 ± 0.73 m/sec) to posttest (5.33 ± 0.79 m/sec) (P = 0.031).
Conclusion: Daily 2000 IU vitamin D supplementation may be effective in optimizing vitamin D status and counteracting the progression of aortic stiffness in black youth. Plasma 25(OH)D concentrations in response to the 2000 IU/d supplementation are negatively modulated by adiposity.
And we'll collect the moments one by one. I guess that's how the future's done. Feist, "Mushaboom", 2005
26/08/2020 10:04 pm
i take 6,000 a day. vit d deficiency seems to be epidemic in this country.
jb
Topic starter
26/08/2020 10:30 pm
like yourself, I follow supplement news. Vit. D is like a rock star. This thing that has caused me the most amazement over the vit. D attention is the fact that we humans were evolved to need sunlight. Vit D is nothing new. Avoiding the sun is. Now with all my basal cell cancers under annual review I am not venturing back into the sun light like I did as a child (getting terrible sun burns), later as a life guard at a pools and summer camps, as a triathlete (in Arizona no less), and in the year or so as a competitive swimmer (also outdoors). Sunlight plays a role in seasonal affective disorder. Here in AZ, I have dx a few cases of SAD's during the summer---it's when we avoid the sun the most. So no one would deny that we, as humans, need clean air and water. Now add sunlight to the list. OR take the pills. There is also some evidence that Vit D needs K2 as a cofactor.
(As a high school junior, I did a study on learning in mice on and off vit K for maze running----boy was I in over my head on that one! The faculty was impressed however! Thank goodness the study was not expected to travel outside the walls of my high school)
And we'll collect the moments one by one. I guess that's how the future's done. Feist, "Mushaboom", 2005
26/08/2020 10:46 pm
i have one of those science fair 1st place winners wherein i postulated energy from nothing and travel at the speed of light. <GRIN>
26/08/2020 11:04 pm
heading to the store now. I hope this isn't like calcium which is now said to cause heart attacks in women because of too high blood levels of calcium.
26/08/2020 11:35 pm
<grin> i have a family member who was just diagnoses with a vit d deficiency. doc just prescribed some vit d supps hat aare 20,000 iu once weekely for a month followed by otc 2,000 daily.
i take 6k daily and get plentyof sun as well.
jb
Topic starter
27/08/2020 12:02 am
heading to the store now. I hope this isn't like calcium which is now said to cause heart attacks in women because of too high blood levels of calcium.
The news story you are referring to is for calcium in supplements and not calcium in food. Further, the report is not mention the use of Vitamin D w. calcium. Calcium should be taken w. D.
And we'll collect the moments one by one. I guess that's how the future's done. Feist, "Mushaboom", 2005
27/08/2020 12:25 am
I supplement with it, thanks for the post HD.
liftsiron is a fictional character and should be taken as such.
27/08/2020 12:48 am
<grin>i take 6k daily and get plentyof sun as well.
jb
I get plenty of sun too. i was wondering if it was a good idea to supplement D. So you think it is, eh?
27/08/2020 1:05 am
Keep in mind that if only your face is getting sun, you have the rest of your body not getting enough vitamin d under normal conditions and your face cannot absorb all the sun you would be getting if you had very little clothing on. At least that's what I read anyway. Anyway, I suffer from SAD and I can't wait to try this this year.
27/08/2020 1:32 am
from the reading i do, i have found no bad side effects from this much d and only potential benefits.
\jb
27/08/2020 1:51 am
My wife tested as low and was taking 50000ius once a week. HOLY
I take 6k per day