Synacthen Depot

Bump.

Any protocol suggestions for the instant version (Synacthen 250mcg amps)?

Hello madtrack.. The brother clarke66 used this protocole:

there are 2 versions of synachten (tetracosactrin). the Synacthen Depot, and Synacthen R.

I always used the Synacthen R, only because it works much faster... the depot is absorbed more slowly as you'd expect.

The Synacthen R comes as a 1ml suspension. I would take 0,25ml i.m. ( upper arm) the evening before a World Championship. Then take another 0,25ml the next morning, after breakfast(6 hours before the race).

Throw the rest of the vial in the trash, as it will not stay fresh.

Other post Importante to respect:

If you're considering using cortico's like celestone, which is an expensive version of betametasone, you'd do best to use 1-1.5mg intravenously 12 hours before the start of your event. However, like with all cortico's you need to test this stuff out in training before racing to find out how much will block you, when you need to dose in order to not be blocked but still feel the effect on race days, etc. IV is a complicated administration route and IM is so much easier. Be forewarned that you will almost always test positive if you've used this shit and have to go to drug control, AND they do a screen for cortico's. There's no hope to put it in via IM OR IV 12-48hrs. before the race and not test positive if they're looking for it.

And remember that any long-term use of cortico's requires supplementation with protein and calcium, and contradicts the use of HGH since they bind to the same cellular receptors...

There is at the moment no test for synacthen as it increases nat cortisone production(WADA are working on it )I have used synacthen depot after my first post and found for me the best results were morning on day before race I also used 0.2ml of (2divisions on syringe) of betamethasone with 1 amp of depot. The quick acting works ;but can take time to kick in ;so is good for 200km + race;(have not used quick acting)Any other info would be appreciated .M/track

A couple of questions on Synacthen Depot. I've gotten some recently but am worried it may not be good since I've read in places that it needs to be kept cool. Mine took quite a while in shipping so I'm sure it got warm for a number of days. Is it still good? Also, I see that MadT took the full amp the morning before the race. I assume you shoot it IM. Advice on protocol would be appreciated.

Thanks.

Yes IM never used coticos IV.Try in training first ,if it blocks u out use lesser dose.I only use 3mg of betamethasone(7mg is 1ml which is the usual therap.dose for patients)M/track

MadT, when did you take the full amp of synacthen depot (morning before, night before, a few hours before) and have you done it by itself to determine the effect?

Posted by: madtrack

Yes IM never used coticos IV.Try in training first ,if it blocks u out use lesser dose.I only use 3mg of betamethasone(7mg is 1ml which is the usual therap.dose for patients)M/track

3mg. is a big dose my friend.

Some cortico info.....

Milligram for milligram, betamethasone is approximately equivalent
to dexamethasone. Betamethasone is the one Madtrack likes most but I have not been able to find it since I saw it years ago at work in the Operating Room.

Dexa and Beta are also 4 to 6 times more potent than methylprednisolone and triamcinolone acetonide(Kenacort or Kenalog), 6 to 8 times more potent than prednisone, 25 to 30 times more potent than hydrocortisone, and about 35 times more potent than cortisone. At equipotent anti-inflammatory doses, dexamethasone almost completely lacks the sodium-retaining property of hydrocortisone.

So 3- 4mg of Betamethasone is equivalent to 20 of triamcinolone acetonide(Kenacort or Kenalog).

Madtrack is correct to use 3-4 mg

Note: You should not do Kenacort IV...it's in Suspension form...not a good idea! From seeing Betamethasone at work in the past I also think it is in a powdery suspension form.
Dexa is done IV in the medical field all the time though.

RG

The more the better you'll go but 3-4mg is still a big dose. A stress free body will produce the equivalent of 20mg. hydrocortisone/day. That's about 3/4mg. dexamethasone. In my experience 6mg. oral kenacort will have you flying. Betemethasone and dexamethasone are basically the same with long half lifes and low mineral retaining properties. At least that's what I've been led to believe.

7mg diprospan(betamethasone) is 1ml,I use 3 stripes on the syringe (3divisions on 1ml syringe)so it is more like 2.5mg.I found this amount worked (most times)I have used less and more and have had breathlessness and blockout from higher doses and not much at all from lower doses.Effect can last 3 days after which normal leg pains return.I have found 48-60hrs after shot is time to race.More info on synacthen R (quick acting would be appreciated) M/track

20 mg of triamc. acet. i.m. work really well... For mi is the best option of cortis ...

Can oral hydrocortisone be effective? what would the equivalent dose of an oral hydrocortisone be?

I see beta is 25-30 times more potent than it, so i guess a dose of 3mg beta = 75-90mg hydrocortiseon, but is it the same for a oral dose?