lower abdomen fat... which is the best cortisol blocking supp?

I know how bad it is. I don't think cortisol is the problem, but genetics. Unfornately to burn fat in this area you will have to do cardio with a good diet, and this can make you leaner.

Or you can think about a lipoaspiration as well...

By the way, a doctor, friend of mine, prescribed me the following formulation (i didn't get it yet). A topical fat burner:

Colleforin (forkollin) 2%
aminofilin 2%
yohimbine 2%
CLA 1%
Cafeisilane C 2%
lanachrys 1%
reguslim 1%

gel light
Qsp 100grs/ 230 grs.
use two times a day in abdominal area

Please, let me know if you are gonna try it.

This might turn out to be an effective topical fat burner.

Glycyrrhetinic acid could be mixed with a penetration enhancer like CEM's USP grade DMSO or PLO gel. It is readily available from China.

Steroids. 2005 Jul;70(8):538-42.

Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application.

Armanini D, Nacamulli D, Francini-Pesenti F, Battagin G, Ragazzi E, Fiore C.

Department of Medical and Surgical Sciences-Endocrinology, University of Padua, Via Ospedale 105, 35100 Padua, Italy.

Cortisol is involved in the distribution and deposition of fat, and its action is regulated by the activity of 11beta-hydroxysteroid dehydrogenase. Glycyrrhetinic acid, the active principle of licorice root, blocks 11beta-hydroxysteroid dehydrogenase type 1, thus reducing the availability of cortisol at the level of adipocytes. We evaluated the effect of topical application of a cream containing glycyrrhetinic acid in the thickness of fat at the level of the thigh. Eighteen healthy women (age range 20-33 years) with normal BMI were randomly allocated to treatment, at the level of the dominant thigh, with a cream containing 2.5% glycyrrhetinic acid (n=9) or with a placebo cream containing the excipients alone (n=9). Before and after 1 month of treatment both the circumference and the thickness of the superficial fat layer of the thighs (by ultrasound analysis) were measured. The circumference and the thickness of the superficial fat layer were significantly reduced in comparison to the controlateral untreated thigh and to control subjects treated with the placebo cream. No changes were observed in blood pressure, plasma renin activity, plasma aldosterone or cortisol. The effect of glycyrrhetinic acid on the thickness of subcutaneous fat was likely related to a block of 11beta-hydroxysteroid dehydrogenase type 1 at the level of fat cells; therefore, glycyrrhetinic acid could be effectively used in the reduction of unwanted local fat accumulation.

"Glycyrrhetinic acid is a pure licorice extract that is known for its skin whitening effect."

hmmm... I hope this wouldnt mess with tanning.

Also, would a 97% purity fine or 98% is required?

Speaking of dosages, 2.5% GA would equal to 2.5 grams in 100 (97.5)grams of carrier, considering purity is not 100%, lets make 95g.
PLO Gel has about 1ml=1g, DMSO is lighter maybe.
Am I correct?

Great info on the GA, I've been doing my homework and found out some negatives such as increase in blood pressure, potassium depletion and also that GA has some mild estrogenic properties which I am not so sure if I understand it, here is an excerpt of an article referring to it:

*2.Licorice root as super antibiotics:anti-inflammatory and anti-allergic effec ts,anti-arthritic properties: Besides treating ulcers along the digestive tract including the mouth, licor ice may be used for viral infections like a cold, inflammation as in arthritis (1 ,2,4), menstrual and menopause disorders (1,4), herpes, eczema and psoriasis (1), allergic disorders, asthma, chronic fatigue, depression due to hormonal imbalanc e, emphysema, and hypoglycemia (3). It has a sweet taste, a neutral energy and a moistening action. (2) Glycyrrhizin is changed in the liver to glycyrrhetinic acid. Both these comp ounds promote the activation of interferon, a potent, naturally produced antivira l compound. Once interferon is activated, white blood cells are also called into play along with killer T cells to help fight against the virus. This is how licor ice exerts its effect on cold viruses, herpes simplex I and possibly even HIV. Li corice also shows some antibacterial effects, but these are due more to the flavo noids than glycyrrhizin. (1,3) Licorice is also known for its anti-inflammatory and anti-allergic effects. This is due to the effect it has on the adrenal glands which are responsible for producing cortisol, the body�s own natural corticosteroid. Once again glycyrrhiz in is responsible. This agent exhibits adaptogenic properties by stimulating cort isol production when there is not enough and promoting the breakdown of cortisol when there is too much. Because of this, licorice is useful to take after stoppin g prescription corticosteroids to boost the natural production of cortisol. It is also given in cases where the adrenal glands are weakened from constant over-sti mulation, as in many autoimmune diseases. Glycyrrhizin also inhibits prostaglandi n production, another component of the inflammatory process. (1,2) Diseases like asthma, chronic fatigue syndrome, and eczema may benefit from this herb. Another adaptogenic effect from licorice involves estrogen. Licorice shows m ild estrogenic properties similar to other phytoestrogens. It has the ability to promote estrogen production and to interfere with the effects of too much estroge n, especially from outside sources. (1,4) The flavonoid constituents are thought to be responsible for the estrogen-like effects, while glycyrrhetinic acid antago nizes estrogen where there is over-stimulation of estrogen receptors in the body. (1) All this makes licorice useful in controlling the menstrual cycle and in rel ieving PMS and menopausal symptoms. Licorice has an expectorant effect, which will benefit people with asthma or chest colds with tight coughs or difficulty breathing. (2,3) It is also a mild l axative. (4) Licorice tea is pleasant tasting and needs no added sugar. It can be made by simmering a few pieces of the root in a pint of water for 15-20 minutes. This can be done 2 or 3 times before new pieces are needed. DGL tablets are avai lable in health food stores and some pharmacies. Licorice may also be found as a tincture. Most licorice candy today is artificially flavored and is not a true so urce of licorice.

Carlo

Posted by: Carlo

Great info on the GA, I've been doing my homework and found out some negatives such as increase in blood pressure, potassium depletion and also that GA has some mild estrogenic properties which I am not so sure if I understand it, here is an excerpt of an article referring to it:

*2.Licorice root as super antibiotics:anti-inflammatory and anti-allergic effec ts,anti-arthritic properties: Besides treating ulcers along the digestive tract including the mouth, licor ice may be used for viral infections like a cold, inflammation as in arthritis (1 ,2,4), menstrual and menopause disorders (1,4), herpes, eczema and psoriasis (1), allergic disorders, asthma, chronic fatigue, depression due to hormonal imbalanc e, emphysema, and hypoglycemia (3). It has a sweet taste, a neutral energy and a moistening action. (2) Glycyrrhizin is changed in the liver to glycyrrhetinic acid. Both these comp ounds promote the activation of interferon, a potent, naturally produced antivira l compound. Once interferon is activated, white blood cells are also called into play along with killer T cells to help fight against the virus. This is how licor ice exerts its effect on cold viruses, herpes simplex I and possibly even HIV. Li corice also shows some antibacterial effects, but these are due more to the flavo noids than glycyrrhizin. (1,3) Licorice is also known for its anti-inflammatory and anti-allergic effects. This is due to the effect it has on the adrenal glands which are responsible for producing cortisol, the body�s own natural corticosteroid. Once again glycyrrhiz in is responsible. This agent exhibits adaptogenic properties by stimulating cort isol production when there is not enough and promoting the breakdown of cortisol when there is too much. Because of this, licorice is useful to take after stoppin g prescription corticosteroids to boost the natural production of cortisol. It is also given in cases where the adrenal glands are weakened from constant over-sti mulation, as in many autoimmune diseases. Glycyrrhizin also inhibits prostaglandi n production, another component of the inflammatory process. (1,2) Diseases like asthma, chronic fatigue syndrome, and eczema may benefit from this herb. Another adaptogenic effect from licorice involves estrogen. Licorice shows m ild estrogenic properties similar to other phytoestrogens. It has the ability to promote estrogen production and to interfere with the effects of too much estroge n, especially from outside sources. (1,4) The flavonoid constituents are thought to be responsible for the estrogen-like effects, while glycyrrhetinic acid antago nizes estrogen where there is over-stimulation of estrogen receptors in the body. (1) All this makes licorice useful in controlling the menstrual cycle and in rel ieving PMS and menopausal symptoms. Licorice has an expectorant effect, which will benefit people with asthma or chest colds with tight coughs or difficulty breathing. (2,3) It is also a mild l axative. (4) Licorice tea is pleasant tasting and needs no added sugar. It can be made by simmering a few pieces of the root in a pint of water for 15-20 minutes. This can be done 2 or 3 times before new pieces are needed. DGL tablets are avai lable in health food stores and some pharmacies. Licorice may also be found as a tincture. Most licorice candy today is artificially flavored and is not a true so urce of licorice.

Carlo

Yes, but Licorice extract as a topical treatment has not been shown to cause increses in blood pressure. But all of these issues seem to be related to injesting licorice root.

But the whole root contains high amounts of potassium which then lowers blood presure. I believe the studies on the blood presure raising effect of licorice are based on the extract alone.

If you read the original abstract I posted you will note that

"No changes were observed in blood pressure, plasma renin activity, plasma aldosterone or cortisol",

This is telling us a couple of things. One, BP elevation is of no concern with topical application, as JGUNS pointed out.

Second, there was no change in plasma cortisol; cortisol was lowered only in the fat cells. This is telling us that little if any of the compound was absorbed systemically (or we would see a drop in whole body, i.e. plasma cortisol.

I think the fears of side effects are unwarranted.

Posted by: Nandi

I think the fears of side effects are unwarranted.

Nandi,

Since i'm really going to try this, what do you think about the tanning issue?

Posted by: Nandi

If you read the original abstract I posted you will note that

"No changes were observed in blood pressure, plasma renin activity, plasma aldosterone or cortisol",

This is telling us a couple of things. One, BP elevation is of no concern with topical application, as JGUNS pointed out.

Second, there was no change in plasma cortisol; cortisol was lowered only in the fat cells. This is telling us that little if any of the compound was absorbed systemically (or we would see a drop in whole body, i.e. plasma cortisol.

I think the fears of side effects are unwarranted.

Thanks ,

I am going to try it regardless of the possible side effects, i already ordered all supplies.
please note that I have read different and conflicting theories on Glycyrrhetinic acid and I am not sure which to believe. Some say it cause water retention ( GAcid ) and some say it does not affect it but acts as a diuretic. ?????
Nandi, can I ask if you know what is the difference between cabernoxolone and Glycyrrhetinic acid ? I know CBX is a derivative of GA AKA 18-beta glycyrrhetinic acid OR enoxolone. My Chinese supplier recomended me t get Cabernoxolone which he claimed is the 'downstream' product of GA ????
I have collected tons of research and like I mentioned some conflict with each other but is there as a reference at least,lol.
I also feel that maybe adding CBX to the GA and maybe some formastane will help if it indeed GA causes some 'mild estrogenic effects'.
So far I got 4OZ of Plogel + 3 grams of GA, 2 grams of CBX. I'll be testing this myself pretty soon and will let you all know

Thanks,

Carlito

Can someone comment on this:

"Another adaptogenic effect from licorice involves estrogen. Licorice shows m ild estrogenic properties similar to other phytoestrogens. It has the ability to promote estrogen production and to interfere with the effects of too much estroge n, especially from outside sources. The flavonoid constituents are thought to be responsible for the estrogen-like effects, while glycyrrhetinic acid antago nizes estrogen where there is over-stimulation of estrogen receptors in the body."

Thanks,

Carlito

whos selling topical Gacid?

Re: lower abdomen fat... which is the best cortisol blocking supp?

Posted by: soshiv

I have a problem with stubborn abdominal fat that accumulates around my lower abdomen (around my belly button). Other than there i am pretty lean (5'10" 162lbs). I have read that this is due to a high level of cortisol. What would be the best supplement to aid in the removal of the fat from this region. Obviously cardio is the way to burn fat but what kind of supplements work best for burning fat in that area? I have read about EAS C3, Relacore, Ab-Solved and others... does anyone have any experience with this area of fat and if so what supplement would work the best for me? Thanks in advance.

androgens,but,diet is the answer.
for example a ckd diet.

(its no a supplement but............ lol.)