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Pro-Hormones and Supplements
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Topic starter
03/06/2020 8:17 am
we have all read about polycosinol and flush free niacin but the real deal is niacin, just plain old niacin wither straight up or the delayed release. imo, the best you can get is the prescription product niaspan delayed release. start at .5g and workup .5 grams every two weeks until you either can not tolerate it anymore or reach ~2g for a few months. research has shown increases to 3g/day with a low incidnce of side effects. so, if your hdl is less than 40, see your doc and ask him to prescribe the niaspan if your insurance will cover it. taken at night with aspirin works well.
jb
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Mayo Clin Proc. 2010 Apr;85(4):365-79.
A "Hot" Topic in Dyslipidemia Management--"How to Beat a Flush": Optimizing Niacin Tolerability to Promote Long-term Treatment Adherence and Coronary Disease Prevention.
Jacobson TA.
Director, Office of Health Promotion and Disease Prevention, Department of Medicine, Emory University, Faculty Office Building, 49 Jessie Hill Jr Dr SE, Atlanta, GA 30303. [email protected].
Niacin is the most effective lipid-modifying agent for raising high-density lipoprotein cholesterol levels, but it also causes cutaneous vasodilation with flushing. To determine the frequency of flushing in clinical trials, as well as to delineate counseling and treatment approaches to prevent or manage flushing, a MEDLINE search was conducted of English-language literature from January 1, 1985, through April 7, 2009. This search used the title keywords niacin or nicotinic acid crossed with the Medical Subject Headings adverse effects and human. Niacin flushing is a receptor-mediated, mainly prostaglandin D(2)-driven phenomenon, the frequency, onset, and duration of which are largely determined by the distinct pharmacological and metabolic profiles of different niacin formulations. Subjective assessments include ratings of redness, warmth, itching, and tingling. In clinical trials, most (>60%) niacin users experienced mild or moderate flushing, which tended to decrease in frequency and severity with continued niacin treatment, even with advancing doses. Approximately 5% to 20% of patients discontinued treatment because of flushing. Flushing may be minimized by taking niacin with meals (or at bedtime with a low-fat snack), avoiding exacerbating factors (alcohol or hot beverages), and taking 325 mg of aspirin 30 minutes before niacin dosing. The current review advocates an initially slow niacin dose escalation from 0.5 to 1.0 g/d during 8 weeks and then from 1.0 to 2.0 g in a single titration step (if tolerated). Through effective counseling, treatment prophylaxis with aspirin, and careful dose escalation, adherence to niacin treatment can be improved significantly. Wider implementation of these measures should enable higher proportions of patients to reach sufficient niacin doses over time to prevent cardiovascular events.
03/06/2020 8:36 am
Thanks for this post JB. My doc told me to stop using test/aas and wouldn't give me niaspan. said to come back to test my hdl's in 6 months. Here's a suggestion for you doc, go f yourself! I'm gonna wait 6months to treat my low hdl? Anyway, I'm taking controlled release niacin before bed 500mg. Also, polycosinol and red yeast rice. You reckon I could/should work up to 2-3g over time if possible? How long might that typically take?
Topic starter
03/06/2020 9:06 am
in the study above they advocated going from .5g to 1 g over the course of 8 weeks. i would suggest increasing by .5g in two weeks to one gram and then staying there for a month and get retested if you can. if no progress on your hdl, then yes, start increasing to 2g and stay there for another two months and retest. i had this similar chat with my doc, told him that i considered my low hdl to be the single most helath threatening issue i had to deal with and if he would not help me i would find a doc that would. and i did! with an hdl of 56 and rising i am very pleased.
jb
03/06/2020 9:26 am
I use it all the time;OTC over here and very inexpensive;slow release is best cos. u dont flush.M/track
Topic starter
03/06/2020 9:54 am
***note the change in dose titration in my post above! increase to 1g/day at night time and stay there for a month. do not forget when retesting to have your liver enzymes checked as well.
jb
03/06/2020 10:22 am
Cool. I've been taking 500mg before bed. will up to 1g in 2 week. Can't wait to see if there's improvement after about a 6 weeks or so.
03/06/2020 10:50 am
My HDL jumped by 15 points after 3 weeks on plain old niacin. I had quickly titrated up to 2g/day. But, WOW!, the itching took a little getting used to...
03/06/2020 11:18 am
Cool, good input. I'm upping to 1g tonight. I'm on 400 tren e/250 test e per week. Not sure how much niacin while help me while on.
03/06/2020 11:42 am
rhino brings up a good point -- does anyone have pre and post niacin hdl levels while on an aas cycle? If so, please also share what AI/ dose you are using.
Topic starter
03/06/2020 12:04 pm
i do not believe that being on will interfere with the hdl increase and i base that strictly on anecdotal evidence. taking aspirin with the niacin will help with the flushing (itching). the funny thing is i used to take staright up niacin just before working out after i took my amino acids and other supps to increase absorbtion and distribution.
jb
03/06/2020 12:32 pm
That's interesting JB...and great news. I'm up to 1gram before bed and so far only slight itching, no hardcore flush as I've experienced before. The only thing that's killing me now is this indigestion from tren? ugh!
Topic starter
03/06/2020 12:55 pm
hey rhino, update please and see my recent post.
jb
03/06/2020 1:17 pm
I'm up to 2 grams before bed. It's amazing how that 1 little 81mg aspirin keeps my skin from catching on fire. haven't tested my lipids yet. plan on doing that soon.
03/06/2020 1:44 pm
I'm up to 2 grams before bed. It's amazing how that 1 little 81mg aspirin keeps my skin from catching on fire. haven't tested my lipids yet. plan on doing that soon.
Any increase in allergy like symptoms, like runny nose, watery eyes etc.?
liftsiron is a fictional character and should be taken as such.
03/06/2020 2:02 pm
nothing.
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