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25/08/2018 10:18 am
Tetrahydrogestrinone is the designer steroid that was made famous by the whole BALCO doping scandal.
THG is similar in structure to Gestrinone, a seldom-used progestin marketed to treat endometriosis . (1) Gestrinone has an obvious structural similarity to trenbolone. However, gestrinone is not a steroid, it is a 19 nor progesterone. The oral availability of this drug was not achieved via the usual alterations to the methyl or ethyl groups, but via the addition of four hydrogen atoms to the ethynyl group of gestrinone , it is broken down to THG (17-ethynyl group to an ethyl group).
Thus with THG you have a slightly altered and modified version of trenbolone. This made THG a novel alteration of a 19 nor progestrone. Completely undetectable by current doping tests, and technically legal (at the time it was first discovered, it has since been banned). (2)THG is more potent then DHT at AR Binding affinity, however one study noted that under in vivo conditions, THG possesses 20% of the potency of DHT in stimulating prostate, seminal vesicle and levator ani muscle weight in the mouse. (3)
THG should impart lean mass gains due to its lack of aromatization to estrogen. Only low doses of THG are necessary (2-5 MG/day), which makes it the most potent steroid of any currently on the market. one study graphs the agonist activity to the Androgen Receptor of THG versus trenbolone and nandrolone:
From the same study: "In the androgen bioassay, [THG] has higher potency than the two comparator androgens, nandrolone, the most widely abused androgen in sports doping, and trenbolone, among the most potent synthetic androgens known "
However, one must note that THG is a potent progestin in which studies show has a remarkable 7 times the potency of Progesterone itself! (2) As a potent progesterone, using this drug with aromatizing steroids may excascerbate the side effects (hair loss, acne, water retention) attributed to these drugs, and since THG is a potent androgen itself, one can expect these side effects with THG alone.
The biggest concern with this drug will be liver toxicity. Due to its high potency on a milligram per milligram basis, one could only surmise that its effects on the liver would be akin to the drug methytrienonolone, which was never released on the market dut to concerns over its hepatoxiticy.
(1) Thevis M, Geyer H, Mareck U, Schanzer W.
screening for unknown synthetic steroids in human urine by liquid chromatography-tandem mass spectrometry.
J Mass Spectrom. 2005 Jul;40(7):955-62.
PMID: 15934041
(2)Death AK, McGrath KC, Kazlauskas R, Handelsman DJ.
Tetrahydrogestrinone is a potent androgen and progestin.
J Clin Endocrinol Metab. 2004 May;89(5):2498-500.
(3) Labrie F, Luu-The V, Calvo E, Martel C, Cloutier J, Gauthier S, Belleau P, Morissette J, Levesque MH, Labrie C.
Tetrahydrogestrinone induces a genomic signature typical of a potent anabolic steroid.
J Endocrinol. 2005 Feb;184(2):427-33.
25/08/2018 11:38 am
Many are wondering as to what THG actually is.
liftsiron is a fictional character and should be taken as such.
25/08/2018 12:35 pm
Excellent J...
One of the thinges I've always wondered is whether athletes were getting away with THG use because WADA had yet to establish a GC/MS thumbprint for the metabolite, or if there is some element of THG that causes the metabolite to be quickly discarded?
My guess is that WADA was just behind the ball, and a long term test for THG is forthcoming.
Any clue what the half-life of THG would be?
25/08/2018 1:32 pm
I found this interestng as well
Topic starter
25/08/2018 2:17 pm
Maybe I missed it but so what is the half life? It degrades very quickly I understand.
The thing I find most striking about it is that while it is no doubt a powerful drug.. mg for mg it is the most powerful steroid available, it's progestenic nature is a HUGE drawback. personally, i wouldn't want to use it.
25/08/2018 3:09 pm
Fascinating, Nandi...I'm going to spend a little time at the UCLA library...
So THG the THG metabolite decays in the GC/MS process. I'd imagine that this is something that WADA has since rectified as there have been a few documented positives for THG.
Madol however...that's a new one.
J...even though THG has a pronounced progestenic nature, couldn't you just play with the dose to avoid the complications?
Topic starter
25/08/2018 3:49 pm
Fascinating, Nandi...I'm going to spend a little time at the UCLA library...So THG the THG metabolite decays in the GC/MS process. I'd imagine that this is something that WADA has since rectified as there have been a few documented positives for THG.
Madol however...that's a new one.
J...even though THG has a pronounced progestenic nature, couldn't you just play with the dose to avoid the complications?
I don't know how you could! The dosage is 1 MG per day! anyway, the progestenic nature is yin and yan with the anabolic effect. you lessen the dosage you will lessen the mass gains.
25/08/2018 4:40 pm
The THG can be bought at the present time? the THG is a product created single for the sportsmen of elite. But not this prohibited?
25/08/2018 5:13 pm
I've never seen it on anybody's list. It still seems like a designer drug. I'm not sure of the usefullness of it except to beat drug tests, and that is probably not likely anymore. JGUNS pointed out some potential negative aspects of the drug that I was not aware of.
Topic starter
25/08/2018 5:52 pm
Yeah, here you have a ultra hepatoxic, ultra progestenic drug, that COULD pass a drug test. Now that the testing screens it out, it is probably DONE. Again, Tren E or A is going to be a better all around drug.
25/08/2018 6:41 pm
I would agree, J. Tren is hard to beat. Drostanolone is another one I would suggest looking into, zankete.
25/08/2018 7:14 pm
Nandi, the THG in efects positives is similare to tren?i can buy THG or is one steroid dificult to find?Thanks
25/08/2018 8:10 pm
Please guys the THG is one steroid in the shops of steroids?Or this steroid cant buy ? Thaks
25/08/2018 8:52 pm
As I mentioned, I've never seen anyone offering it for sale on the internet. You won't find it in a pharmacy or granero, that's for sure. I suspect when Balco went down, so did THG. But there may be other designer drug companies making; I just don't know.
Desoxy-methyl testosterone, or DMT, is another designer drug recently discovered by the authorities that until recently was also undetectable.
26/08/2018 4:14 am
Thanks nandi and DMT is similare in efect to THG? What is the efects of this new steroid?
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