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15/12/2023 12:19 am
Here is a tentative structure for THG. I am not 100% sure as the name tetrahydrogestrinone is not very specific. This is my best guess at the moment based on the structure of gestrinone. Gestrinone has relative binding affinities(RBA) for the progesterone receptor (PR) and androgen receptor (AR) of 76 and 83 versus progesterone and Testosterone respectively. This means that gestrinone has roughly equal affinity for the PR and AR (a ratio of 1). Trenbolone, on the other hand has RBA's of 74 and 197 for the PR and AR respectively (a ratio of 2.67 AR:PR). I would guess that THG would have a profile similar to that of gestrinone (a ratio closer to 1) with possibly a little more AR affinity. This depends on the molecule being enzymatically converted to a 3-one in the body. If not, then you are left with a relatively less active diol.
Topic starter
15/12/2023 12:36 am
THG
Topic starter
15/12/2023 1:01 am
gestrinone
15/12/2023 1:20 am
So it would be quite a bloating steroid, similair to deca cosmetically? What is the PR and AR affinity of deca please? Thx
15/12/2023 1:44 am
alright seth havent seen you about lately. So with the prog receptor affinity does that meen it would be very prone to causing gyno? I cant dowload the bmps, but if you have them on jpeg I can download them. This steroid as you know was up until recently undetectable. question is how does one get into the loop to know this info and why didnt WE know about it? Im desperate to get back into sport but am juiced up - but if there was an undetectable roid that would be good -rather than have to shoot Suspension and stuff. How many people had access to THG? Cheers bro.
Topic starter
15/12/2023 2:04 am
Nandrolone has binding affinities of 20 and 154 for PR and Ar respectively. The main difference is that nandrolone can convert to estrogen and trenbolone can not. This is one of the reasons why there is a such a variety in the bloating and gyno response to tren. It will depend a lot on a persons native estrogen levels and with what the trenbolone is taken with. Also, People tend to take larger doses of nandrolone. Apparently, this steroid was made by one lab and developed strictly to beat drug tests and was delivered to only a few select people. If you want to beat drug tests then you can't have everyone knowing about it. I can guarantee you that there are other "undetectable" designer steroids in use that we don't know about. In my opinion, there are much better ways to beat drug tests than to use an untested drug like thg. Sorry I don't have these pictures in any other format than bmp. I have been around. I mostly lurk unless I see something that interests me. I was doing a lot for a while over at elite, but at some point it came down to signing up for a platinum membership and I don't think I should be paying to give people advice. I have actually been paying a lot of attention to the prosteroid realm (1-test, methyl 1-test, hydroxytest) simply because it is "new" and offers me some opportunity to experiment within the law (for now).
This post was modified 3 weeks ago by Admin
15/12/2023 2:21 am
Originally posted by stan alright seth havent seen you about lately. So with the prog receptor affinity does that meen it would be very prone to causing gyno? I cant dowload the bmps, but if you have them on jpeg I can download them. This steroid as you know was up until recently undetectable. question is how does one get into the loop to know this info and why didnt WE know about it? Im desperate to get back into sport but am juiced up - but if there was an undetectable roid that would be good -rather than have to shoot suspension and stuff. How many people had access to THG? Cheers bro. Hey Stan, I converted the files into jpeg format for ya, hope ya dont mind Seth. Anyways Seth are you studying Organic Chem? If ya are I'd be keen to have a chat as I'm doing a fair bit at Uni too. -BAZ
15/12/2023 2:50 am
and the other
Topic starter
15/12/2023 3:17 am
I've been out of college for quite a while now, but organic chem was one of the things I studied.
15/12/2023 3:40 am
Cheers Seth, and thanks BigAussieZee
15/12/2023 4:07 am
I hope to have a voice from Seth 'cause recently I've tried to figure out a chemical drawing for THG. After some thinking I've pulled out these two alternative... both different from yours...since you surely has more experience than me in chemistry...please tell me what do you think about... what are my mistake... And a last question...could you suggest me a good book about anabolic steroids chemistry...an universitary or researcher text??? I've read "Anab. Steroids" of H.L. Kruskemper dated 1968...a little bit old 🙁 (sorry for the english...) Thanks very much in advance... under my ideas for THG... V.
15/12/2023 4:31 am
Others configurations...
15/12/2023 4:48 am
Tetrahydrogestrinone would be the structure on the top right (the one without the 2 double bonds b/w C9-10, and C11-12). Plus lose the ketone at C3, its a hydroxy group until metabolized (according to the first structure by seth of gestrinone). I say that b/c the double bond b/w C4-5 is required for activity (for testosterone).
15/12/2023 5:11 am
Originally posted by durabol Tetrahydrogestrinone would be the structure on the top right (the one without the 2 double bonds b/w C9-10, and C11-12). Plus lose the ketone at C3, its a hydroxy group until metabolized (according to the first structure by seth of gestrinone). I say that b/c the double bond b/w C4-5 is required for activity (for testosterone). Sorry...Thg originally has a keto group in C-3...in the body this group became an hydroxy group by means of 3beta-enzyme???...
Topic starter
15/12/2023 5:30 am
The compound on the upper right is norgestrel. I guess it is possible that they would have hydrogenated the triple bond to produce an ethyl group. If the people who produced it new anything they would no that traditionally, tetrahydrosteroids involve the reduction of the 5-alpha and 3-keto double bonds. This produces a molecule with exactly 4 more hydrogens than the parent molecule. Take the case of nandrolone and tetrahydronandrolone as in the attachment.
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