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12/10/2018 5:47 am
Med Sci Sports Exerc. 2006 Feb;38(2):256-61. Related Articles, Links
Chronic administration of anabolic androgenic steroid alters murine thyroid function.
Fortunato RS, Marassi MP, Chaves EA, Nascimento JH, Rosenthal D, Carvalho DP.
1Endocrine Physiology Laboratory, and 2Cardiac Electrophysiology Laboratory, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, BRAZIL.
PURPOSE:: The administration of anabolic-androgenic steroids (AAS) to improve athletic performance has increased notably during the past three decades, even among nonathletes. Thyroid function is affected by AAS use in humans, although the mechanisms of the effects of AAS are unclear. We evaluated the effects on thyroid function of supraphysiologic doses of nandrolone decanoate (DECA), which is one of the most anabolic-androgenic steroids (AAS) used. METHODS:: Male Wistar rats were treated with vehicle or 1 mg.100 g body weight (b.w.) of DECA, once a week for 8 wk, intramuscularly. We analyzed thyroperoxidase (TPO) activity, type 1 iodothyronine deiodinase (D1) activities in liver, kidney, pituitary, and thyroid, and serum levels of total t3, total T4, free T4, and TSH. Parametric and nonparametric t-tests were employed for statistical analyses. RESULTS:: Treated animals showed a significant increase in the weight of kidneys and heart, and a decrease in the relative testis weight. Retroperitoneal adipose tissue was only slightly decreased. deca treatment induced a significant increase in the absolute and relative thyroid gland weight. The concentrations of total serum T3, free T4, and TSH decreased significantly with treatment, but total serum T4 levels were unchanged. Thyroperoxidase activity was unaltered, whereas liver and kidney D1 activities were significantly increased, but pituitary and thyroid D1 did not change. CONCLUSION:: Our data indicate that DECA exerts direct actions on the thyroid gland and in the peripheral metabolism of thyroid hormones and might lead to thyroid dysfunction.
12/10/2018 6:38 am
The real question would be; how long it would take to reach a level of true (clinical) dysfunction?
12/10/2018 7:18 am
acecombact1 -- Could you give us more information on Materials and Methods?
"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.
12/10/2018 7:50 am
"Chronic administration" = 8 weeks?
12/10/2018 8:51 am
"Chronic administration" = 8 weeks?
Hope it helps bro.
Acute means sudden or brief. It can be used to describe either an exposure or a health effect. An acute exposure is a short-term exposure. Short-term means lasting for minutes, hours or days.
Chronic means long-term or prolonged. A chronic exposure is a long-term exposure. Long-term means lasting for weeks, months or years.
So it seems that the authors are right, sorry.
"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.
Topic starter
12/10/2018 9:26 am
acecombact1 -- Could you give us more information on Materials and Methods?
sorry bro but i cant find full text anywhere.
12/10/2018 11:08 am
I think that the key phrase is MIGHT lead to thyroid dysfunction, it also MAY not. It's to bad comparable studies arn't done on willing human subjects instead of rats.
liftsiron is a fictional character and should be taken as such.
12/10/2018 11:40 am
I think that the key phrase is MIGHT lead to thyroid dysfunction, it also MAY not. It's to bad comparable studies arn't done on willing human subjects instead of rats.
I agree, on the other hand I think interventions with animals are important because they represent the first findings that can eventually be confirmed or not by human clinical studies.
"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.