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06/07/2019 9:00 pm
Lovejoy JC, Bray GA, Bourgeois MO, Macchiavelli R, Rood JC, Greeson C, Partington C. Exogenous androgens influence body composition and regional body fat distribution in obese postmenopausal women--a clinical research center study. J Clin Endocrinol Metab. 1996;81(6):2198-203.
ABSTRACT
Abdominal fat distribution is influenced by androgen levels in both men and women. The purpose of this study was to assess the effects on fat distribution of administering nandrolone decanoate (ND; an anabolic steroid with weak androgenic activity) or Spironolactone (SP; an antiandrogen) in obese postmenopausal women. The design was a randomized, placebo-controlled, 9-month trial with simultaneous calorie restriction for weight loss. Women in all three groups lost comparable amounts of weight, but the ND-treated women gained lean mass relative to the other two groups (P < 0.0005) and lost more body fat than women in the SP group (P < 0.01). The resting metabolic rate also increased slightly in the ND group. ND treatment produced a gain in visceral fat, as determined by computed tomography scan, and a relatively greater loss of sc abdominal fat. SP-treated women lost significantly less sc fat than the other two groups. Serum cholesterol decreased in the placebo group, but increased slightly in the other two groups (significant for SP vs. placebo, P < 0.05). High density lipoprotein cholesterol decreased significantly in the ND-treated women. There were no significant changes in fasting glucose or insulin sensitivity. We conclude that administration of exogenous androgens modulates body composition in obese postmenopausal women and independently affects visceral and sc abdominal fat.
"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.
06/07/2019 9:30 pm
the problem is that this study was done on obese postmenopausal women.
jb
Topic starter
06/07/2019 9:53 pm
Indeed, every single study published so far has at least one important bias, it all depends on the eyes on the beholder .
"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.
06/07/2019 10:15 pm
good experimental design must insist that conclusions drawn from a particular study must be limited to the population the study sample was drawn from. any extrapolation really should be phrased as "a topic for more study".
jb
Topic starter
06/07/2019 10:32 pm
Come on my friend JB, how many studies that we quote (and extrapolate as well) here are not always limited to the population the study sample? But it's not a sin, nor a bad thing. As you know when we don't have enough studies in a given field of study, every single study counts!
"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.
06/07/2019 11:02 pm
i was simply stating a caveat that we should all be aware of, so, while we all find these studies interesting, we do not draw any conclusions from them wrt ourselves until we have some form of verification. THat is why we bring it all to the table, personal opinions, experiences, on point research, research that while not based on a sample population that includes us might be worth examining to see if any gems of truth or insight reside therein. We just have to be careful of the conclusions we draw. That is why it is always like a gift from heaven when we see an abstract that that has a sample drawn from a population of healthy young men, or healthy trained athletes that actually do the things we are considering and the results are measured in a double blind crossover paradigm.
jb
Topic starter
06/07/2019 11:20 pm
Well put.
"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.
06/07/2019 11:38 pm
good experimental design must insist that conclusions drawn from a particular study must be limited to the population the study sample was drawn from. any extrapolation really should be phrased as "a topic for more study".jb
or an intricate logical reasoning chain.
dr frankenstein
06/07/2019 11:57 pm
jb