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Topic starter
23/10/2018 4:30 pm
OK, not sure if I read it here or some where else.
Someone was saying that cialis raised test levels.
Does anyone have this study?
Topic starter
23/10/2018 5:28 pm
Bump
23/10/2018 6:10 pm
perhaps this is the study you were looking for:
jb
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Testosterone:estradiol ratio changes associated with long-term tadalafil administration: a pilot study.Greco EA, Pili M, Bruzziches R, Corona G, Spera G, Aversa A.
Internal Medicine, Department of Medical Pathophysiology, University of Roma La Sapienza, Rome, Italy.
INTRODUCTION: It has been reported that lack of sexual activity due to erectile dysfunction (ED) may be associated with Testosterone(T) decline. AIM: To investigate whether the known changes in sex hormones associated with resumption of sexual activity are sustained in the long term. MAIN OUTCOME MEASURES: Primary endpoints were variations from baseline of steroid hormones: total T, free T (f T), and estradiol (E). Secondary endpoints were variations of erectile function domain scores at International Index of Erectile Function-5 (IIEF-5). METHODS: In an open-label fashion, 20 patients (mean age 54.8 +/- 8.4 years) received tadalafil 10-20 mg on demand for 12 months. Exclusion criteria were those reported for phosphodiesterase inhibitors, including hypogonadism and hyperprolactinemia. RESULTS: Tadalafil assumption was safe and well tolerated (overall adverse effects in 15% of patients) and none discontinued medication. A significant decrease in E levels occurred at the end of the study (from 19.9 +/- 9.6 to 16.6 +/- 8.1 ng/dL, P = 0.042 vs. baseline), with parallel increase in the T:E ratio (26.3 +/- 15.3 to 32.6 +/- 17.7, P = 0.05), whereas no changes in T and f T serum levels were observed, respectively (411.4 +/- 131.4 to 434.2 +/- 177.1 ng/dL and 47.7 +/- 15.3 to 49.9 +/- 19.1 pmol/L, not significant). Interestingly, nonparametric subgroup analysis for related samples revealed that E decrease was detectable only in lean (N = 14) but not in obese (N = 6, body mass index > 27.5 kg/m2) subjects (17.8 +/- 10.1 vs. 13.5 +/- 6.8, P < 0.05). A net increase in IIEF-5 scores was observed at the endpoint (13.7 +/- 5.9 vs. 25.7 +/- 2.9, P < 0.0001). CONCLUSIONS: Sustained improvement in sexual function after 12 months of tadalafil administration is associated with increased T:E ratio mainly related to reduction of E levels. We hypothesize that androgen-estrogen cross-talk and possible inhibition of aromatase activity during chronic exposure to tadalafil might have a role in the regulation of erectile function.
Topic starter
23/10/2018 6:51 pm
Interesting.
nonparametric subgroup analysis for related samples revealed that E decrease was detectable only in lean (N = 14) but not in obese (N = 6, body mass index > 27.5 kg/m2) subjects
Notice how the fatter counterparts had higher estrogen?
I suspect this was aromatase activity.
23/10/2018 7:29 pm
that would make sense.
jb
Topic starter
23/10/2018 8:00 pm
Great post by the way JB...........