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19/10/2018 6:07 am
Benefits Of Estrogen On Building Muscle I've always believed having a healthy balance of estrogen is best. For joints, libido, etc....
But the question came up between some friends and I..."Is estrogen really beneficial in building muscle?". What positive effects dose it have? I just KNEW it had to have some kind of positve effects...why else would the body produce it naturally?
In my quest to finding answers I was discouraged to find this study.
Estrogen suppression in males: metabolic effects.
Mauras N, O'Brien KO, Klein KO, Hayes V.
Nemours Research Programs at the Nemours Children's Clinic, Jacksonville, Florida 32207, USA.
quote:
We have shown that Testosterone(T) deficiency per se is associated with marked catabolic effects on protein, calcium metabolism, and body composition in men independent of changes in GH or insulin-like growth factor I production. It is not clear,,however, whether estrogens have a major role in whole body anabolism in males. We investigated the metabolic effects of selective estrogen suppression in the male using a potent aromatase inhibitor, Arimidex(Anastrozole). First, a dose-response study of 12 males (mean age, 16.1 +/- 0.3 yr) was conducted, and blood withdrawn at baseline and after 10 days of oral Arimidex given as two different doses (either 0.5 or 1 mg) in random order with a 14-day washout in between. A sensitive estradiol (E2) assay showed an approximately 50% decrease in E2 concentrations with either of the two doses; hence, a 1-mg dose was selected for other studies. Subsequently, eight males (aged 15-22 yr; four adults and four late pubertal) had isotopic infusions of [(13)C]leucine and (42)Ca/(44)Ca, indirect calorimetry, dual energy x-ray absorptiometry, isokinetic dynamometry, and growth factors measurements performed before and after 10 weeks of daily doses of Arimidex. Contrary to the effects of T withdrawal, there were no significant changes in body composition (body mass index, fat mass, and fat-free mass) after estrogen suppression or in rates of protein synthesis or degradation; carbohydrate, lipid, or protein oxidation; muscle strength; calcium kinetics; or bone growth factors concentrations. However, E2 concentrations decreased 48% (P = 0.006), with no significant change in mean and peak GH concentrations, but with an 18% decrease in plasma insulin-like growth factor I concentrations. There was a 58% increase in serum T (P = 0.0001), sex hormone-binding globulin did not change, whereas LH and FSH concentrations increased (P < 0.02, both). Serum bone markers, osteocalcin and bone alkaline phosphatase concentrations, and rates of bone calcium deposition and resorption did not change. In conclusion, these data suggest that in the male 1) estrogens do not contribute significantly to the changes in body composition and protein synthesis observed with changing androgen levels; 2) estrogen is a main regulator of the gonadal-pituitary feedback for the gonadotropin axis; and 3) this level of aromatase inhibition does not negatively impact either kinetically measured rates of bone calcium turnover or indirect markers of bone calcium turnover, at least in the short term. Further studies will provide valuable information on whether timed aromatase inhibition can be useful in increasing the height potential of pubertal boys with profound growth retardation without the confounding negative effects of gonadal androgen suppression.
Anyone care to share or want to disprove this study? LOL
19/10/2018 6:48 am
Just my 2 cents.
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Mauras N, Hayes V, O'Brien KO. Estrogen treatment and estrogen suppression: metabolic effects in adolescence. J Pediatr Endocrinol Metab. 2000;13 Suppl 6:1431-7.
ABSTRACT
The metabolic consequences of reaching full reproductive maturity in humans involve not only growth hormone (GH) and insulin-like growth factor-I, but also the collaborative interaction of the gonadal sex steroids. Estrogen is critical for completing linear growth. It also inhibits bone resorption, decreases plasma lipid levels and serves as an antiatherosclerotic agent. Our studies show that, in low doses, estrogen increases GH production, increases calcium absorption and decreases bone turnover; however, unlike testosterone, estrogen has no effects as a protein-anabolic agent, at least at the whole body level. Studies of selective estrogen suppression, achieved using a potent aromatase inhibitor, show that estrogen is the main regulator of the gonadotropin axis. In boys, selective aromatase blockade may have a role in delaying epiphyseal fusion. Large placebo-controlled trials will be required to study this effect further.
"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.
19/10/2018 7:48 am
The problem I have is that this study does not consider the effects (if any?) estrogen contributes in people on AAS.
19/10/2018 8:47 am
People who have extensively used AAS know there is some anabolic benefit derived from estrogen, although what exactly is not clear, and the relative contribution is minimal compared to the rest.
For trenbolone at least, animal studies seem to explain it as estrogen preferentially being metabolized, thereby enhancing the effect of trenbolone.
Good things come to those who weight.
The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.
Topic starter
19/10/2018 9:38 am
The problem I have is that this study does not consider the effects (if any?) estrogen contributes in people on AAS.
Very true...
Thanks for the study, guijr.
19/10/2018 10:38 am
I think that alot of people believe that the excess bloat one gets when a high degree of estrogen is present which increases weight and aids strength is anabolic. IMO it's just bloat. Although I don't believe it wise to try and totally eliminate estrogen either because that also leads to problems as was mentioned as lowered libido, sore joints and most importantly atrieal plaque formation.
In normal men the body has a balance between testosterone and estrogen so it makes sense to me that during a cycle it makes sense to try and regulate the balance between the two hormones to get maximun desired benefit. The amount of AI used no doubt would vary from individual to individual.
liftsiron is a fictional character and should be taken as such.
19/10/2018 11:23 am
What's the best AI available and why?
"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.
19/10/2018 11:55 am
What's the best AI available and why?
That agin would be personal preference. I perfer arimidex because it doesn't effect my libido although letro and aromasin are both more effective.
liftsiron is a fictional character and should be taken as such.