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Topic starter
22/09/2018 1:32 pm
17beta-Trenbolone . ALRI is selling this attached to an ester.
i just want to know how can they sell this stuff legaly?
also isnt this compound supposed to be realy liver toxic? Like methyl tren?
Effects of an androgenic growth promoter 17beta-trenbolone on masculinization of Mosquitofish (Gambusia affinis affinis).
Sone K, Hinago M, Itamoto M, Katsu Y, Watanabe H, Urushitani H, Tooi O, Guillette LJ Jr, Iguchi T.
Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan.
Endocrine disrupting chemicals can affect normal hormone dependent processes through numerous mechanisms, including ligand mimicky. 17beta-Trenbolone (TB), a pharmaceutical, androgenic, anabolic steroid, is a potent agonist of androgen receptors, and has been extensively used as a growth promoter for beef cattle in the US. The effects of TB on adult and newborn mosquitofish (Gambusia affinis affinis) were examined. Two forms of mosquitofish androgen receptor (AR), ARalpha and ARbeta, were cloned. The mRNA expression levels of ARalpha and ARbeta were transiently increased in the anal fin of adult females at day 3 following exposure to TB (1-10 microg/L) or methylTestosterone(MT) (0.1-10 microg/L), a pharmaceutical androgen used as a positive control. Gonopodium differentiation from the adult female anal fin was induced after 28 days of exposure to TB (1-10 microg/L) or MT (0.1-10 microg/L). Gonopodium differentiation also was induced in all mosquitofish fry exposed for 28 days to 0.3, 1 or 10 microg/L TB. Furthermore, spermatozoa were observed histologically in the testes of male fry exposed for 28 days to 1 or 10 microg/L TB; spermatozoa are normally observed only in the testes of mature males. Surprisingly, all female fry exposed for 28 days to 1 or 10 microg/L TB displayed the formation of an ovotestis, as spermatozoa were found in the ovary. Thus, TB, like MT, induced masculinization of the anal fin accompanied by a transient up-regulation of ARalpha and ARbeta in adult females. TB also induced differentiation of the anal fin into a gonopodium in fry of both sexes, stimulated precocious spermatogenesis in the testes of males and the formation of ovotestes in females.
Topic starter
22/09/2018 2:11 pm
Ok in another study claims that 17beta-trenbolone (17beta-TbOH), the active compound after trenbolone acetate (TBA) administration.
Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine progestin receptor.
Bauer ER, Daxenberger A, Petri T, Sauerwein H, Meyer HH.
Institut fur Physiologie, Research Center for Milk and Food Weihenstephan, Technical University Munich, Germany.
For the steroidal growth promoters trenbolone acetate (TBA) and melengestrol acetate (MGA) neither the complete spectrum of biological activities nor the potential endocrine disrupting activity of their excreted metabolites in the environment is fully understood. The potency of these substances in [3H]dihydrotestosterone ([3H]-DHT) displacement from the recombinant human androgen receptor (rhAR) and from human sex-hormone binding globulin (hSHBG) was evaluated. In addition, the potency for [3H]-ORG2058 displacement from the bovine uterine progestin receptor (bPR) was tested. For comparison, different anabolics and synthetic hormones were also tested for their binding affinities. For 17beta-trenbolone (17beta-TbOH), the active compound after TBA administration, an affinity the rhAR similar to dihydrotestosterone (DHT) and a slightly higher affinity to the bPR than progesterone were demonstrated. The affinity of the two major metabolites, 17alpha-trenbolone and trendione, was reduced to less than 5% of the 17beta-TbOH-value. The affinity of these three compounds and of MGA to the hSHBG was much lower compared with DHT. MGA showed a 5.3-fold higher affinity than progesterone to the bPR but only a weak affinity to the rhAR. The major MGA metabolites have an affinity to the bPR between 85% and 28% of the affinity of progesterone. In consequence, MGA and TBA metabolites may be hormonally active substances, which will be present in edible tissues and in manure. We conclude that detailed investigations on biodegradation, distribution and bio-efficacy of these substances are necessary.
23/09/2018 8:01 am
I would doubt that it is legal.
jb
23/09/2018 8:58 am
hmm, post the web page at ALRI, i can not seem to find it on their site.
jb
23/09/2018 9:31 am
hmm, post the web page at ALRI, i can not seem to find it on their site.jb
They pulled all their quasi-legal steroids on the 26th I believe due to the increased scrutiny from government establishments and the media.
Additionally, it�s been speculated the Washington Post article was a contributing factor in their decision making process.
Only I Can Stop Me.
Aspartame killed my father.. and raped my Mother!
Topic starter
23/09/2018 10:14 am
I think ALRI is playing with fire here
23/09/2018 11:14 am
i find it interesting that the spelling is trienbolone, i wonder if that is a mistake or something else is going on. I also wonder what the oral bioavailability would be. In anycase, it is more expensive that good old trenbolone acetate which we all know works!
jb
23/09/2018 11:58 am
trienbolone is an acceptable alterantive for trenbolone and basically 17-beta-trenbolone is trenbolone. They only refer to it as such to distinguish it from the highest excreted (inactive) metabolite, 17-alpha-trenbolone.
By no rights should this be legal, but ALRI has apparently ( I only learned this recently) also been selling Madol (DMT) and 17-alpha-methyl-drostanolone. By what possible loophole they haven't been busted for this, is unclear to me. Other companies selling this stuff seem to go over the matter very lightly in discussing it on message boards. SO there must be some loophole.
Oral bio-availability is not that high, lower than 15%, i found it in the lit somewhere long time ago.
Good things come to those who weight.
The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.
23/09/2018 12:49 pm
so a good guess would be that taking these po would not be very effective.
jb
23/09/2018 1:43 pm
Lets say you'd need somewhere around 250-300 mg per day to get the same effect as 75 mg eod injects of Tren Ace. It would work, but it seems like a terrible waste.
I've seen people do it actually, chew 220-240 mg worth of pellets each day, in 2 doses, and get results, but even at that dose, not the results most of us have come to associate with trenbolone use.
Good things come to those who weight.
The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.
23/09/2018 2:44 pm
I just clicked the link though, it seems to concern 17b-methoxy-trenbolone and not 17b-trenbolone. Such a compound is, as listed, a progestin. The increased distance between the 3-keto and the C-17-O-C-19 would make androgen binding much less favourable, and the 3 double bonds already seem to have a higher affinity for the progesterone receptor than the androgen receptor. 17b-methoxy compounds in experimental stages are also listed with a U, indicating progesterone activity. If there was notably tendency towards androgen binding, then the letter R would be used as well.
Good literature to look into if this interests you are the completed works of Ojasoo and Raynaud, especially their studies on unique steroid congeners for receptor studies, and CFA analysis of steroid libraries.
Like one of the links said, they are just pickint these things from Vida. And I don't think in this day and age, and on this board I need to explain the inaccuracy of the testing they used to determine anabolic and androgenic tendencies of steroids. Moreover they say it is X times stronger than trenbolone, I'm not at all sure that doesn't refer to the progestagenic activity.
Good things come to those who weight.
The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.
23/09/2018 3:22 pm
I have no clue how effective this will be (the ALRI stuff) but my thoughts, and i am not the chemist, are that it will be both potent and VERY toxic or it will be weak and VERY toxic.
23/09/2018 4:07 pm
jb
23/09/2018 4:41 pm
Given that it has no functional OH group, due to the methyl group on the oxygen atom, androgen binding should be considerably weaker, androgen action probably even weaker. On the other hand both the 4,9,11-trien structure and the C-17 methoxy group are known to increase progesterone receptor binding and progestin action.
Even if some people find the anabolic action sufficient (they sell the stuff mostly to non-steroid-users), the extremely high progestagenic action would keep me from even trying it.
Good things come to those who weight.
The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.
Topic starter
23/09/2018 5:27 pm
BC dont you think that this compound would have no affinity to androgen receptor? the smallest alteration of the Ligand can abolish the biding affinity. This compound must be converted back to into the 17beta-hydroxyl compound to be active. to do so, you would have to break the ether bond. this is a saturated ether, so its very stable, and that means it will not hydrolyze or break down unless under extreme chemical conditions. I dont think that the human body has an enzyme that can catalyze such reaction
So i think this copound may be inactive.