HMG protocol?

HMG is a combinaton of synthetic LH and FSH. They are most often in a 50/50 ratio.

If memory serves me correctly, 150ius of FSH would be sufficient EOD. I would run 300ius of LH EOD, one would have to add some HCG to the protocol.

Sorry for the lack of refs. If you want them, shoot me a pm to remind me and I'll shoot them to you as soon as my schedule isn't so hectic.

What makes HMG any better than HCG ?

Hot Rocks

I just thought HMG was more potent and also caused an increase and volume and sperm quality. I'd never heard you'd need to use both hcg and hmg to regulate testes during cycle.

Some more info:

Here's some info on it:

Gonadotropin treatment for infertility
Examples
Brand Name Chemical Name
A.P.L., Pregnyl, Profasi
human chorionic gonadotropin (hCG)

Bravelle, Humegon, Metrodin, Pergonal, Repronex
human menopausal gonadotropin (hMG)

Follistim, Gonal-F
recombinant human follicle-stimulating hormone (rFSH)

The body produces two types of gonadotropins: follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Once they are produced by the pituitary gland, gonadotropins trigger production of other sex hormones. Gonadotropins therefore play a part in egg and sperm production, as well as female and male physical traits such as voice, muscle, hair, and breast development.

Human menopausal gonadotropin (hMG) and recombinant human follicle-stimulating hormone (rFSH) are gonadotropin fertility drugs.

* hMG contains natural FSH and LH, purified from urine from postmenopausal women. (After menopause, women produce high levels of gonadotropins, which are excreted in their urine.)
* rFSH is genetically synthesized in the laboratory.

Human chorionic gonadotropin (hCG) is similar to LH; it contains equal amounts of LH and FSH. These hormones play a central role in egg production.
How It Works

In women. Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are necessary for egg production (ovulation). Early in the menstrual cycle, a woman with low hormone levels who is not ovulating can have daily human menopausal gonadotropin (hMG) or recombinant human FSH (rFSH) injections for an average of 12 days. If this helps develop mature follicles, the ovary is ready to ovulate. One dose of human chorionic gonadotropin (hCG) is then used to stimulate ovulation.

In men with low Testosterone and FSH. LH stimulates the production of testosterone, and FSH promotes the formation of sperm. If a semen analysis, LH, and FSH testing suggest that abnormal hormone levels are preventing sperm production, these gonadotropins may be prescribed to promote sperm formation together. hCG is injected 3 times weekly until blood testosterone level is within the normal range (this may take 4 to 6 months). Treatment continues with injections of hCG twice a week and hMG or FSH 3 times a week until the sperm count rises to normal levels.
Why It Is Used

Gonadotropins are given by injection to help the body make hormones needed for egg or sperm production.

In women. Gonadotropins may be used:1

* To stimulate ovulation related to low natural gonadotropin or estrogen levels. (This is most commonly seen in women with excessive exercise or eating disorders.)
* When clomiphene and metformin have been ineffective for correcting irregular or no ovulation caused by polycystic ovary syndrome (PCOS).
* For developing multiple egg follicles on the ovaries. Multiple eggs are harvested and used in assisted reproductive techniques such as in vitro fertilization or gamete intrafallopian transfer.
* In combination with intrauterine insemination for couples with unexplained infertility when clomiphene has not worked.

In men. Gonadotropin therapy can treat low sperm counts caused by low levels of natural gonadotropins.
How Well It Works

The combination human menopausal gonadotropin (hMG)/human chorionic gonadotropin (hCG) or recombinant human follicle-stimulating hormone (rFSH)/ hCG treatment can consistently stimulate ovulation. It results in pregnancy in 60% of women failing to ovulate. However, of those pregnancies, up to 35% end in miscarriage.2
Side Effects

Side effects are more common and more serious with gonadotropin treatment than with clomiphene (clomid).

* Up to 35% of women who become pregnant after hMG/hCG or rFSH/hCG therapy have a miscarriage.2 This is higher than the risk of miscarriage in the general population.
* In 5% to 10% of treatment cycles, women develop detectable ovarian enlargement. Multiple follicles (cysts with eggs) make the ovaries larger and more tender.2
* There is a risk of ovarian hyperstimulation syndrome (OHSS), which (rarely) can be life-threatening. When closely monitored for side effects, however, a woman has less than a 1% risk of developing severe OHSS.2
* Ovarian stimulation increases the likelihood of multiple pregnancy (twins, triplets, or more). Multiple pregnancy is considered high-risk for both a mother and her fetuses.
* Other side effects include headache and abdominal pain.
* Men may experience temporary breast enlargement.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
What To Think About

During gonadotropin treatment, frequent monitoring of egg follicle development is necessary.2 This is done with ultrasound and blood tests. Without careful monitoring, the ovaries may become hyperstimulated. Ovarian hyperstimulation syndrome can be a very serious condition. It usually goes away by itself in 2 to 4 weeks, but a woman may need bed rest or hospitalization and intravenous fluid therapy, or may need a procedure to remove fluid from the abdomen.

Gonadotropins should only be used by doctors who are specially trained in infertility and who are familiar with the management of possible complications.

Complete the new medication information form (PDF)Click here to view a form.(What is a PDF document?) to help you understand this medication.
References

Citations

1. Yao MWM, Schust DJ (2002). Treatment options section of Infertility. In JS Berek, ed., Novak''s Gynecology, 13th ed., pp. 1018–1036. Philadelphia: Lippincott Williams and Wilkins.
2. Mishell DR Jr (2001). Infertility. In MA Stenchever et al., eds., Comprehensive Gynecology, 4th ed., pp. 1169–1215. St. Louis: Mosby.
Author: Bets Davis, MFA Last Updated: April 7, 2006
Medical Review: Joy Melnikow, MD, MPH - Family Medicine
Kathleen Romito, MD - Family Medicine
Kirtly Jones, MD - Obstetrics and Gynecology

more info, different source:

Human Menopausal Gonadotropins (hMG)

If you're having difficulties getting pregnant because of menstrual irregularities, you may want to ask you're doctor about the fertility drug: Human menopausal gonadotropin (hMG). hMG is typically given to females undergoing fertility treatments like IFV and IUI to induce ovulation. hMG contains the luteinizing hormone (LH) and follicle-stimulating hormone (FSH)— the two crucial hormones needed to stimulate ovulation. hMG like the fertility drug Urofollitropin is extracted from the urine of post-menopausal women and then purified before use.

How hMG Works and Its Effectiveness

Human menopausal gonadotropins stimulate the pituitary gland to release the hormones: LH and FSH. These hormones released by hMG combine forces to aid in the development and release of the egg by a woman's follicles. Once the matured egg is released into the fallopian tubes, it is ready to be fertilized.

Help Treat

Human menopausal gonadotropins are most likely to increase the odds of conception, improving fertility in women who suffer from fertility problems including:

* Endometriosis
* Low levels of LH
* Low levels of FSH
* Ovary disorders like PCOS

Women who do not respond to the infertility drug Clomid can also use hMG.

Using HMG and Side Effects

Your doctor may recommend you to take human menopausal gonadotropins two to three days after your menstruation starts, for up seven to twelve days. Although, your dose of hMG will depend on your condition, the average dose of hMG recommended is between 75 and 600 IU per day. hMG are taken in the form of intramuscular injections.

A common side effect of hMG is hyperovarian stimulation. This occurs when the ovaries respond too well to the fertility drug. As a result the body releases multiple follicles into the ovaries. The release of multiple eggs can also increase the risk of multiple births by 40 percent while using hMG. Another side effect woman may notice while using this infertility drug to treat includes mood swings.

Here's some info about HCG so you can compare

What is Human Chorionic Gonadotropin?

Human Chorionic Gonadotropin (hCG) is a hormone that helps regulate the corpus lutem, a follicle that produces an egg for ovulation. hCG also stimulates the production of the two crucial hormones – estrogen and progesterone – needed to carry pregnancy to term. Normally, hCG is used in infertility treatments to trigger ovulation. hCG is extracted from the urine of pregnant women after being produced by the placenta.

How HCG Works

The HCG hormone works similar to the lutenizing hormone (LH) secreted by the pituitary gland. While the main function of LH is to the release the egg down the fallopian tube, hCG works to increase the number of eggs produced by the ovaries each month. With an increase number of eggs, the chance of fertilization increases.

Human Chorionic Gonadotropin Helps Treat

In women, human chorionic gonadotropin can help treat irregularities in ovulation, such as the following conditions:

* anovulation
* irregular menstruation
* polycystic ovary syndrome (PCOS)

In men, hCG can be used to increase the level of testosterones and sperm.

Taking hCG and Success Rates

hCG is taken in the form of an injection. Your fertility doctor will administer one dose of hCG during each cycle of your infertility treatment. Your fertility specialist may show you how and when to administer the injections yourself. But, either way your fertility doctor will need to monitor your progress, and will give you and your partner a guideline regarding timed intercourse, to increase chances of conception.

HCG has proven effective in inducing ovulation; in fact 90 percent of the women taking this fertility drug ovulate after receiving treatment. On average, hCG increases pregnancy rate by 15 percent per a cycle. But this percentage increases with the use of the artificial insemination procedure:IUI.

Side Effects and Risks of hCG

Like most fertility treatments, hCG may cause you to experience some side effects. Some common side effects and risks of hCG include:

* abdominal discomfort
* headaches
* mood changes
* nausea
* indigestion
* sore breasts
* tiredness
* water retention
* weight gain
* risk of multiple births

would 75 or would 150 be better 3 days before a race? Is this detectable in testing yet?

I've seen most use it either EOD or m/w/f......but if I had the money, i'd take it ED at 75iu like the studies use I believe.

fstbiker, i'd not bother using it as a performance enhancer, you will most likely be disappointed.

BMJ

So would it be good as a PCT ?

Posted by: kapus

So would it be good as a PCT ?

Yes.

I thought you wouldn't use hcg or hmg during pct but leading up to it, meaning before all exo hormones have left your body.

Posted by: rhinofight

I thought you wouldn't use hcg or hmg during pct but leading up to it, meaning before all exo hormones have left your body.

. Right, because hmg/hcg stimulates lh which does make testcles sensitive to it but doesn't restore the HPTA. The HPTA is restored by blocking estrogen from ers in the hypothalamus thru serms or ais. Using hcg/hmg prior to pct will make it go much smoother.

Posted by: rhinofight

I thought you wouldn't use hcg or hmg during pct but leading up to it, meaning before all exo hormones have left your body.

You're right. I always considered pct to start the day after one's last shot. In this instance, I was thinking of hmg being used like this:

And calling weeks 10-16 pct. I should have been more clear.

That makes sense!

Posted by: ready2explode

You're right. I always considered pct to start the day after one's last shot. In this instance, I was thinking of hmg being used like this:

Weeks 1-10: test
Weeks 10-12: hmg
Weeks 10-16: nolva

And calling weeks 10-16 pct. I should have been more clear.

. I've done this exact protocol with hcg. Works fine. I figured that you meant something like this. Some ppl get stupid with hcg.

Can HMG be reconstituted with BAC and stored in fridge?