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21/09/2019 4:06 am
Protective and regenerative effects of the GH/IGF-I axis on the brain.Isgaard J, Aberg D, Nilsson M.
Laboratory of Experimental Endocrinology, Department of Internal Medicine, University of Göteborg, Göteborg, Sweden [email protected].
Apart from regulating somatic growth and metabolism, evidence suggest that the GH/ IGF-I axis is involved in the regulation of brain growth, development and myelination. More-over, growth hormone (GH) and particularly IGF-I have been attributed neuroprotective effects in different in vitro and in vivo experimental models. In addition, both GH and IGF-I affect cognition and biochemistry in the adult brain. Some of the effects of GH are suggested to be mediated by circulating IGF-I, while other effects may be due to locally produced IGF-I within the brain. It is also possible that GH may act directly on the central nervous system (CNS) without involving IGF-I (either circulating or locally). Plasticity in the CNS may be viewed as changes in the functional interplay between the major cell types neurons, astrocytes and oligodendrocytes. GH and IGF-I affect all these cell types in several aspects. Apart from neuroprotective effects of GH and IGF-I in different experimental models of CNS injury, IGF-I has been found to increase progenitor cell proliferation and new neurons, oligodendrocytes, and blood vessels in the dentate gyrus of the hippocampus. In the adult cerebral cortex, it appears that only oligodendrogenesis is affected. The increase of IGF-I on endothelial cell phenotype may explain the increase in cerebral arteriole density observed after GH treatment. In the present review, different aspects of the GH/IGF-I axis effects on the brain will be discussed with particular emphasis on neuroprotection, regeneration and brain plasticity. Moreover, recent findings describing neuroprotective effects and effects on synaptic plasticity by GH secretagogues will be reviewed.
21/09/2019 4:23 am
Some day when I have enough money I'll use GH...
"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.
21/09/2019 4:50 am
Is is just as good (and cheaper) to just take IGF-1 and not the HgH?
Topic starter
21/09/2019 5:14 am
good question. most take the HGH to get the increased igf. Up until recently i would tell you not to waste your money on igf but the lst 2 mg of igf i did have almost made me a believer. I am going to do another 2 mg to see if i see a similar effect.
if money is imited i would say start off with a couple mg of igf and see how that treats you. remember, $1200 of jins will not beat the results from a couple hundred bucks worth of test.
jb