HCG and adipose tis...
 
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HCG and adipose tissue

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jboldman
(@jboldman)
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Joined: 7 years ago
Posts: 1450
Topic starter  

effects of HCG on adipose tissue, not good news.

jb

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In vitro effects of chorionic gonadotropin hormone on human adipose development.Dos Santos E, Dieudonné MN, Leneveu MC, Pecquery R, Serazin V, Giudicelli Y.
Service de Biochimie et Biologie Moléculaire, UPRES EA 2493, Faculté de Médecine Paris-Ile de France Ouest, Centre hospitalier de Poissy, Université Versailles St Quentin, 78303 Poissy Cedex, France.

It is well known that pregnancy is associated with fat weight gain. However, the mechanisms whereby fat mass accumulation is controlled during this period are poorly understood. Therefore, we attempted to determine whether human chorionic gonadotropin (HCG), in vitro, influences human adipose tissue development and/or metabolism. For the first time, HCG/LH receptor was characterized in human adipose cells. We also demonstrated that physiological concentrations of HCG, while unaltering both lipolysis and expression of two markers of lipogenesis (FAS and ADD1) in human mature adipocytes, stimulate human preadipocyte growth via the activation of a protein kinase A-independent mitogen-activated protein kinase/c-fos signaling pathway. HCG also moderately increases the preadipocyte differentiation capacityas reflected by enhanced glycerophosphate dehydrogenase activity and expression of key adipogenic transcriptional factors (C/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2). Finally, HCG significantly stimulates the secretion of the proadipogenic factor, leptin, from human adipose tissue. Taken altogether, these data suggest that the proadipogenic effect of HCG in human preadipocytes contributes to explain why increased fat storage occurs during the first trimester of pregnancy.


   
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oswaldosalcedo
(@oswaldosalcedo)
Estimable Member
Joined: 6 years ago
Posts: 243
 

interesting.

cool find.

dr frankenstein


   
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(@jupiter)
New Member
Joined: 5 years ago
Posts: 2
 

jboldman, due you feel the proadipogenic effect of hcg could happen on someone taking hcg during TRT?


   
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jboldman
(@jboldman)
Member
Joined: 7 years ago
Posts: 1450
Topic starter  

i have not heard of this happening and have not experienced it myself. while there may be a proadipogenic effect it may be outweighed by other factors such as the Testosterone as well as training and diet.

jb


   
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(@jupiter)
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Joined: 5 years ago
Posts: 2
 

Thanks


   
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