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06/07/2018 9:47 am
Cancer. 1994 Jul 1;74(1):74-7. Related Articles, Links
tamoxifen administration is associated with a high rate of treatment-limiting symptoms in male breast cancer patients.
Anelli TF, Anelli A, Tran KN, Lebwohl DE, Borgen PI.
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
BACKGROUND. Although an uncommon disease, male breast cancer (MBC) will be responsible for 300 deaths in 1993 in the United States. Because of the high rate of estrogen receptor positivity in males, adjuvant hormonal therapy with tamoxifen in the adjuvant setting has been used widely. Little is known about the side effects of this estrogen receptor blocker in males. METHODS. The authors evaluated the side effects of adjuvant tamoxifen treatment in 24 patients (19 of whom were estrogen receptor positive) treated at the authors' institution between 1990 and 1993. RESULTS. Fifteen (62.5%) patients reported at least one side effect. The most common side effect was a decrease in libido, which occurred in 7 (29.2%) patients; followed by weight gain, which occurred in 6 (25%) patients; hot flashes, which occurred in 5 (20.8%); mood alterations, which occurred in 5 (20.8%); depression, which occurred in 4 (16.6%); insomnia, which occurred in 3 (12.5%); and deep venous thrombosis, which occurred in 1 (4.2%). Five (20.8%) patients terminated treatment with tamoxifen in less than 1 year because of these side effects. Two of these patients had decreased libido, two had hot flashes, and one suffered deep venous thrombosis. CONCLUSIONS. In contrast to female breast cancer patients, who have a 4% attrition rate to adjuvant tamoxifen treatment, MBC patients have a 20.8% attrition rate related to side effects of tamoxifen treatment
06/07/2018 10:36 am
you have to wonder what it would be if they had been treated with clomid9merely a hypothetical thought here since i know that Clomid is not used for this), a drug that is not without its own side effects. In fact most frequent comments i hear are guys switching to Nolvadex because of the side effects of Clomid. I have tried to find other studies reporting this but usually only find cookie cutter warnings on websites about possible side effects.
The research is much more definitive wrt nolvadex and lipid profiles than it is for Clomid. I wonder if raloxifene would not do the same without the sides reported for both Clomid and nolvadex.
jb
06/07/2018 11:25 am
Decrease in libido, weight gain,mood alterations, depression,
Anyone tthink that these conditions may have occurred because the subjects were dying of cancer and not because of the nolvadex. We have so many studies in regard to AI's, AE's etc. in very sick and dying people where their entire system is fucked up and shutting down. Healthy bodybuilders do not react the same to these drugs.
liftsiron is a fictional character and should be taken as such.
Topic starter
06/07/2018 12:24 pm
there are a lot of people who report the same things with nolva, they just attribute it to post cycle related issues (when in point of fact its likely that the PCT itself is causing those effects)
06/07/2018 1:24 pm
Nolva is no friend of mine too,and the same goes for its younger brother,toremifen.
Both are used because of their high affinity for breast tissue and are very weak estrogens in their action.But it seems my organism recognizes both as quite strong estrogens .They both make me bloat within days (talking about 10 pounds of water in 4 days ) and make my breast tissue sensitive and sore.Last time i used toremifene i got those effects and quit cold turkey,and lasix helped me with the water gain or i'd have a heart attack from the increased blood pressure.Clomid is even worse.
So it's not only about people being sick to death reporting tamoxifen is making them sick,bloated,get the flu and the like.
Interestingly,raloxifene works like magic without any of the bad sides.That's what i call individualized reaction to drugs.
06/07/2018 1:57 pm
there are a lot of people who report the same things with nolva, they just attribute it to post cycle related issues (when in point of fact its likely that the PCT itself is causing those effects)
I think the more likely culprit is just post cycle. I can remember to old days when PCT was virtually unheard of. The majority experienced decrease in libido, weight gain,mood alterations, depression. IMO pct decreases the symptoms somewhat. Clomid though seems to make men far more emotional though, I remember tearing up watching movies on Clomid. Regardless bro the study was a good find, thanks for posting.
liftsiron is a fictional character and should be taken as such.
Topic starter
06/07/2018 2:30 pm
IMO Clomid is a better choice, with respect to libido, most men report increased drive with it (though the tearing up is a bit much for some)
08/07/2018 7:43 am
IMO Clomid is a better choice, with respect to libido, most men report increased drive with it (though the tearing up is a bit much for some)
Agreed!
liftsiron is a fictional character and should be taken as such.
Topic starter
08/07/2018 8:33 am
Agreed!
you have to wonder what it would be if they had been treated with Clomid9merely a hypothetical thought here since i know that Clomid is not used for this), a drug that is not without its own side effects. In fact most frequent comments i hear are guys switching to nolvadex because of the side effects of Clomid. I have tried to find other studies reporting this but usually only find cookie cutter warnings on websites about possible side effects.
The research is much more definitive wrt nolvadex and lipid profiles than it is for Clomid. I wonder if raloxifene would not do the same without the sides reported for both Clomid and nolvadex.
jb