Notifications
Clear all
Topic starter
28/08/2018 5:35 am
Fertil Steril. 1978 Mar;29(3):320-7. Related Articles, Links
Hormonal effects of an antiestrogen, tamoxifen, in normal and oligospermic men.
Vermeulen A, Comhaire F.
The administration of tamoxifen, 20 mg/day for 10 days, to normal males produced a moderate increase in luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, and estradiol levels, comparable to the effect of 150 mg of clomiphene citrate (clomid). However, whereas Clomid produced a decrease in the LH response to LH-releasing hormone (LHRH), no such effect was seen after the administration of tamoxifen. In fact, prolonged treatment (6 weeks) with tamoxifen significantly increased the LH response to LHRL. Treatment of patients with "idiopathic" oligospermia for 6 to 9 months resulted in a significant increase in gonadotropin, testosterone, and estradiol levels. A significant increase in sperm density was observed only in subjects with oligospermia below 20 X 10(6)/ml and normal basal FSH levels. When basal FSH levels were increased or oligospermia was moderate (greater than 20 X 10(6)/ml); no effect on sperm density was seen. As sperm density increased, FSH levels decreased, suggesting an inhibin effect. Sperm motility was not improved by tamoxifen treatment. In five boys with delayed puberty, tamoxifen treatment appeared to activate the pituitary-gonadal axis and pubertal development.
Anyone have the full article?
how could i get it? local university?
anyone know how much of a certain dose of Nolvadex increses a certain amoutn of test?
28/08/2018 6:53 am
My library may have it. I will check for you on Monday. Or I could go to the source if you have specific questions. Professor Comhaire teaches at my college, and I have done internships in his andrology lab.
Good things come to those who weight.
The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.
Topic starter
28/08/2018 7:50 am
Dont go thru all that im just looking for an avg # for free test increase in relation to dosages.
thanx appreciate it
29/08/2018 3:49 am
Copied it today :
n = 6
Age = between 33 and 70
Dose = 20 mg/day
duration = 10 days
LH levels increased and plateaud 3 days into the treatment at 150 +/- 20 %. Parallel with that mean T levels increased to a plateau of 142 +/- 11% of basal values and E2 levels increased to 151 +/- 20% of basal levels.
Interestingly, right below that paragraph the authors note (and figures are provided) that this effect was slightly weaker than 3 daily doses of 50 mg of clomid.
Good things come to those who weight.
The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.
Topic starter
29/08/2018 4:47 am
"However, whereas Clomid produced a decrease in the LH response to LH-releasing hormone (LHRH), no such effect was seen after the administration of tamoxifen."
...........this is why Nolvadex is more interesting. Remember, that one week off after 3 weeks on one would need to get the GNRH/or LHRH goin again for that week.
....im surprised about the E increase
granted it might of been biased P. arnold did a study with his 6-0xo & it raised total test 188% & free test 266%. They peaked at the 3 week mark, little too long for my 1 week need.
BC any other ideas what one could use during that 1 week to stim GHRH/LHRH?
29/08/2018 5:23 am
The E increase seems to parallel the test increase, this seems very normal. Don't forget that estrogen action is blunted. This may lead to upregulation of aromatase, but given that it is not significantly above T, I'd imagine its just the result of the increased substrate.
With 6-Oxo things are different. 6-oxo if I'm not mistaken is an AI. Effects would indeed take longer to be noticable and a larger increase in Testosterone seems probable given that none of it will convert to estrogens.
I commented on the role of glucocorticoids in inhibiting hypothalamic effects in HPTA, and that arginine might benefit in this regard. That may be one thing to look into.
Good things come to those who weight.
The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.