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Topic starter
07/07/2019 7:02 am
Am J Physiol Endocrinol Metab. 2006 Sep 19
Are blood flow and lipolysis in subcutaneous adipose tissue influenced by contractions in adjacent muscles in humans?
Stallknecht B, Dela F, Helge JW.
Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Aerobic exercise increases whole-body adipose tissue lipolysis, but is lipolysis higher in subcutaneous adipose tissue (SCAT) adjacent to contracting muscles than in SCAT adjacent to resting muscles? Ten healthy, overnight-fasted males performed one-legged knee extension exercise at 25% of maximal workload (Wmax) for 30 minutes followed by exercise at 55% Wmax for 120 minutes with the other leg and finally exercised at 85% Wmax for 30 minutes with the first leg. Subjects rested for 30 minutes between exercise periods. Femoral SCAT blood flow was estimated from washout of (133)Xe and lipolysis was calculated from femoral SCAT interstitial and arterial glycerol concentrations and blood flow. In general, blood flow as well as lipolysis was higher in femoral SCAT adjacent to contracting than adjacent to resting muscle (time 15-30 min: blood flow: 25% Wmax: 6.6 +/- 1.0 vs. 3.9 +/- 0.8 ml 100 g(-1) min(-1), P < 0.05; 55% Wmax: 7.3 +/- 0.6 vs. 5.0 +/- 0.6, P < 0.05; 85% Wmax: 6.6 +/- 1.3 vs. 5.9 +/- 0.7, P > 0.05; lipolysis: 25% Wmax: 102 +/- 19 vs. 55 +/- 14 nmol 100 g(-1) min(-1), P = 0.06; 55% Wmax: 86 +/- 11 vs. 50 +/- 20, P > 0.05; 85% Wmax: 88 +/- 31 vs. -9 +/- 25, P < 0.05). In conclusion, blood flow and lipolysis are generally higher in SCAT adjacent to contracting than adjacent to resting muscle irrespective of exercise intensity. Thus, specific exercises can induce "spot lipolysis" in adipose tissue. Key words: exercise, spot lipolysis, microdialysis.
dr frankenstein
07/07/2019 7:28 am
Perhaps doing 400 sit-ups a day will really work after all
07/07/2019 7:53 am
damn, there goes another one!
jb
07/07/2019 8:12 am
So Arnold and Zane were right! Let's do hundreds of abdominal exercises. Good post bro.
"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.
07/07/2019 8:40 am
I just got the full article, sees well designed so far.
"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.
Topic starter
07/07/2019 8:57 am
I just got the full article, sees well designed so far.
hi guijr
it outlines,explicitly fat mobilization and fat oxidation ?
it refer about and fatty acids and glycerol by products? trans-delta2-enoyl-CoA,3-ketoacyl CoA,acetyl CoA,glyceraldehyde 3-phosphate.
can you send me the article?
dr frankenstein
07/07/2019 9:22 am
hi guijrit outlines,explicitly fat mobilization and fat oxidation ?
it refer about and fatty acids and glycerol by products? trans-delta2-enoyl-CoA,3-ketoacyl CoA,acetyl CoA,glyceraldehyde 3-phosphate.
can you send me the article?
Yes, no problem. Well, it's done, check your mail box. Enjoy and post the answers of your questions, OK?
"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.
Topic starter
07/07/2019 9:43 am
Yes, no problem. Well, it's done, check your mail box. Enjoy and post the answers of your questions, OK?
thanks! guijr
dr frankenstein
07/07/2019 10:00 am
Any updates on the article oswaldosalcedo?
07/07/2019 10:28 am
Is anyone really that surprised? It just seems wrong for a working muscle to use fuel from anywhere but the closest available site (even thought it doesn't actually work this way since FA's released from adipose are first transported in the blood to the heart and then disributed).
However, I'd question the significance and practicality of this, based on what we know regarding the dynamic system that is the human body and the literature in this particular area. The inconsistency of the findings regarding spot reduction is, IMO, why I think the spot reducing phenomena is of very low significance.
In the discussion, they cited local temperature increases leading to increased blood flow, and subsequent increases in Epinephrine levels. They offered paracrine signaling as another method of local lipolytic induction.
Thoughts?
Only I Can Stop Me.
Aspartame killed my father.. and raped my Mother!
07/07/2019 10:44 am
Is anyone really that surprised? It just seems wrong for a working muscle to use fuel from anywhere but the closest available site (even thought it doesn't actually work this way since FA's released from adipose are first transported in the blood to the heart and then disributed).However, I'd question the significance and practicality of this, based on what we know regarding the dynamic system that is the human body and the literature in this particular area. The inconsistency of the findings regarding spot reduction is, IMO, why I think the spot reducing phenomena is of very low significance.
In the discussion, they cited local temperature increases leading to increased blood flow, and subsequent increases in Epinephrine levels. They offered paracrine signaling as another method of local lipolytic induction.
Thoughts?
My thoughts are that a small amount of lipolysis from everywhere through HSL makes more sense than a large bias in favor of local tissues. However with that said, perhaps the local tissue forms the original and largest link in the chain.
Topic starter
07/07/2019 11:07 am
Any updates on the article oswaldosalcedo?
give me time,i have to think at the same time several things (other topics).
and in this case,i have seen all the contrary (in previous studies).
dr frankenstein